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Simvastatin Attenuation of Cerebral Vasospasm After Subarachnoid Hemorrhage in Rats Via Increased Phosphorylation of Akt and Endothelial Nitric Oxide Synthase

The mechanisms involved in simvastatin-mediated attenuation of cerebral vasospasm after subarachnoid hemorrhage (SAH) are unclear. We investigated the role of the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway and endothelial nitric oxide synthase (eNOS) in the cerebral vasculature in statin-m...

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Detalhes bibliográficos
Main Authors: Sugawara, Takashi, Ayer, Robert, Jadhav, Vikram, Chen, Wanqiu, Tsubokawa, Tamiji, Zhang, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691855/
https://ncbi.nlm.nih.gov/pubmed/18683242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.21807
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