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Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data

The aim of this study was to demonstrate the value of mechanistic simulations in gaining insight into the behaviors of modified release (MR) formulations in vivo and to use the properly calibrated models for prediction of pharmacokinetics (PK) and pharmacodynamics (PD). GastroPlus(TM) (Simulations P...

詳細記述

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書誌詳細
主要な著者: Lukacova, Viera, Woltosz, Walter S., Bolger, Michael B.
フォーマット: Artigo
言語:Inglês
出版事項: Springer US 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691467/
https://ncbi.nlm.nih.gov/pubmed/19430911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-009-9107-2
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