Cationic lipid/DNA complexes (JVRS-100) combined with influenza vaccine (Fluzone(®)) increases antibody response, cellular immunity, and antigenically drifted protection

Safe and effective adjuvants for influenza vaccines that could increase both the levels of neutralizing antibody, including against drifted viral subtypes, and T-cell immunity would be a major advance in vaccine design. The JVRS-100 adjuvant, consisting of DOTIM/cholesterol cationic liposome-DNA com...

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Main Authors: Lay, Marla, Callejo, Bernadette, Chang, Stella, Hong, David K., Lewis, David B., Carroll, Timothy D, Matzinger, Shannon, Fritts, Linda, Miller, Christopher J, Warner, John F., Liang, Lily, Fairman, Jeffery
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2690618/
https://ncbi.nlm.nih.gov/pubmed/19406188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.04.054
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