An Iminohydantoin Lesion Induced in DNA by Peracids and Other Epoxidizing Oxidants

The oxidation of guanine to 5-carboxamido-5-formamido-2-iminohydantoin (2-Ih) is shown to be a major transformation in the oxidation of the single-stranded DNA 5-mer d(TTGTT) by m-CPBA and DMDO as a model for peracid oxidants and in the oxidation of the 5-base pair duplex d[(TTGTT)·(AACAA)] with DMD...

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Autori principali: Ye, Wenjie, Sangaiah, R., Degen, Diana E., Gold, Avram, Jayaraj, K., Koshlap, Karl M., Boysen, Gunnar, Williams, Jason, Tomer, Kenneth B., Mocanu, Viorel, Dicheva, Nedyalka, Parker, Carol E., Schaaper, Roel M., Ball, Louise M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2690081/
https://ncbi.nlm.nih.gov/pubmed/19354244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8090752
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