Decreased Catecholamine Degradation Associates with Shock and Kidney Injury after Cardiac Surgery

Enzymatic pathways involving catechol-O-methyltransferase (COMT) catabolize circulating catecholamines. A G-to-A polymorphism in the fourth exon of the COMT gene results in a valine-to-methionine amino acid substitution at codon 158, which leads to thermolability and low (“L”), as opposed to high (“...

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Bibliographic Details
Main Authors: Haase-Fielitz, Anja, Haase, Michael, Bellomo, Rinaldo, Lambert, Gavin, Matalanis, George, Story, David, Doolan, Laurie, Buxton, Brian, Gutteridge, Geoff, Luft, Friedrich C., Schunck, Wolf-Hagen, Dragun, Duska
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2009
Subjects:
Clinical Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689901/
https://ncbi.nlm.nih.gov/pubmed/19406978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008080915
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