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Decreased Catecholamine Degradation Associates with Shock and Kidney Injury after Cardiac Surgery
Enzymatic pathways involving catechol-O-methyltransferase (COMT) catabolize circulating catecholamines. A G-to-A polymorphism in the fourth exon of the COMT gene results in a valine-to-methionine amino acid substitution at codon 158, which leads to thermolability and low (“L”), as opposed to high (“...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society of Nephrology
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2689901/ https://ncbi.nlm.nih.gov/pubmed/19406978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008080915 |
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