Germline and somatic JAK2 mutations and susceptibility to chronic myeloproliferative neoplasms

Myeloproliferative neoplasms (MPNs) are a group of closely related stem-cell-derived clonal proliferative diseases. Most cases are sporadic but first-degree relatives of MPN patients have a five- to seven-fold increased risk for developing an MPN. The tumors of most patients carry a mutation in the...

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Bibliographic Details
Main Authors: Goldin, Lynn R, Björkholm, Magnus, Kristinsson, Sigurdur Y, Samuelsson, Jan, Landgren, Ola
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689447/
https://ncbi.nlm.nih.gov/pubmed/19490586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm55
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