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Exploiting the promiscuity of imatinib

The protein kinase inhibitor imatinib, also known as Gleevec, has been a notable success in treating chronic myelogenous leukemia. A recent paper in BMC Structural Biology reports a 1.75 Å crystal structure of imatinib bound to the oxidoreductase NQO2 and reveals insights into the binding specificit...

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Hlavní autoři: Lee, Shun J, Wang, Jean YJ
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689438/
https://ncbi.nlm.nih.gov/pubmed/19435483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/jbiol134
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