The Immunosuppressive Properties of the HIV Vpr Protein Are Linked to a Single Highly Conserved Residue, R90

BACKGROUND: A hallmark of AIDS progression is a switch of cytokines from Th1 to Th2 in the plasma of patients. IL-12, a critical Th1 cytokine secreted by antigen presenting cells (APCs) is suppressed by Vpr, implicating it as an important virulence factor. We hypothesize that Vpr protein packaged in...

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Detalhes bibliográficos
Main Authors: Tcherepanova, Irina, Starr, Aijing, Lackford, Brad, Adams, Melissa D., Routy, Jean-Pierre, Boulassel, Mohamed Rachid, Calderhead, David, Healey, Don, Nicolette, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689350/
https://ncbi.nlm.nih.gov/pubmed/19516896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005853
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