Vα24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages

Tumor infiltration with Vα24-invariant NKT cells (NKTs) associates with favorable outcome in neuroblastoma and other cancers. Although NKTs can be directly cytotoxic against CD1d(+) cells, the majority of human tumors are CD1d(–). Therefore, the role of NKTs in cancer remains largely unknown. Here,...

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Detalhes bibliográficos
Main Authors: Song, Liping, Asgharzadeh, Shahab, Salo, Jill, Engell, Kelly, Wu, Hong-wei, Sposto, Richard, Ara, Tasnim, Silverman, Ayaka M., DeClerck, Yves A., Seeger, Robert C., Metelitsa, Leonid S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689106/
https://ncbi.nlm.nih.gov/pubmed/19411762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37869
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