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Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation
Thalidomide is a potent teratogen that induces a range of birth defects, most commonly of the developing limbs. The mechanisms underpinning the teratogenic effects of thalidomide are unclear. Here we demonstrate that loss of immature blood vessels is the primary cause of thalidomide-induced teratoge...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2688998/ https://ncbi.nlm.nih.gov/pubmed/19433787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901505106 |
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