Guanylyl Cyclase C Prevents Colon Cancer Metastasis by Regulating Tumor Epithelial Cell Matrix Metalloproteinase 9

Matrix metalloproteinase 9 (MMP-9) produced by colorectal cancer cells is a critical determinant of metastatic disease progression and an attractive target for antimetastatic strategies to reduce colon cancer mortality. Cellular signaling by cGMP regulates MMP-9 dynamics in various cell systems and...

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Bibliografiske detaljer
Main Authors: Lubbe, Wilhelm J., Zuzga, David S., Zhou, Zengyi, Fu, Weili, Pelta-Heller, Joshua, Muschel, Ruth J., Waldman, Scott A., Pitari, Giovanni M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688960/
https://ncbi.nlm.nih.gov/pubmed/19336567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0067
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