Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis

Although sufficient cholesterol supply is known to be crucial for neurons in the developing mammalian brain, the cholesterol requirement of neural stem and progenitor cells in the embryonic central nervous system has not been addressed. Here we have conditionally ablated the activity of squalene syn...

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Detalhes bibliográficos
Main Authors: Saito, Kanako, Dubreuil, Veronique, Arai, Yoko, Wilsch-Bräuninger, Michaela, Schwudke, Dominik, Saher, Gesine, Miyata, Takaki, Breier, Georg, Thiele, Christoph, Shevchenko, Andrej, Nave, Klaus-Armin, Huttner, Wieland B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688855/
https://ncbi.nlm.nih.gov/pubmed/19416849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903541106
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