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ROS, Hsp27, and IKKβ Mediate Dextran Sodium Sulfate (DSS) Activation of IκBa, NFκB, and IL-8

BACKGROUND: Dextran sodium sulfate (DSS) is a sulfated polysaccharide that has been very widely used to induce inflammation in experimental models of inflammatory bowel disease in which the effects of pharmacologic and biologic therapies are tested. However, the precise mechanisms by which DSS induc...

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Autori principali: Bhattacharyya, Sumit, Dudeja, Pradeep K., Tobacman, Joanne K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688460/
https://ncbi.nlm.nih.gov/pubmed/19085995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.20821
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