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Crystallization and preliminary X-ray diffraction analysis of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil

Uridine phosphorylase (UPh; EC 2.4.2.3) catalyzes the phosphorolytic cleavage of the N-glycosidic bond of uridine to form ribose 1-phosphate and uracil. This enzyme also activates pyrimidine-containing drugs, including 5-fluorouracil (5-FU). In order to better understand the mechanism of the enzyme–...

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Main Authors: Lashkov, A. A., Gabdoulkhakov, A. G., Shtil, A. A., Mikhailov, A. M.
格式: Artigo
語言:Inglês
出版: International Union of Crystallography 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688420/
https://ncbi.nlm.nih.gov/pubmed/19478441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109016133
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