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A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family history

INTRODUCTION: Unclassified variants (UVs) in the BRCA1/BRCA2 genes are a frequent problem in counseling breast cancer and/or ovarian cancer families. Information about cancer family history is usually available, but has rarely been used to evaluate UVs. The aim of the present study was to identify w...

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Bibliografski detalji
Glavni autori: Gómez García, Encarna B, Oosterwijk, Jan C, Timmermans, Maarten, van Asperen, Christi J, Hogervorst, Frans BL, Hoogerbrugge, Nicoline, Oldenburg, Rogier, Verhoef, Senno, Dommering, Charlotte J, Ausems, Margreet GEM, van Os, Theo AM, van der Hout, Annemarie H, Ligtenberg, Marjolijn, van den Ouweland, Ans, van der Luijt, Rob B, Wijnen, Juul T, Gille, Jan JP, Lindsey, Patrick J, Devilee, Peter, Blok, Marinus J, Vreeswijk, Maaike PG
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687711/
https://ncbi.nlm.nih.gov/pubmed/19200354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2223
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