The Degree of Folding Instability of the Envelope Protein of a Neurovirulent Murine Retrovirus Correlates with the Severity of the Neurological Disease

A small group of ecotropic murine retroviruses cause a spongiform neurodegenerative disease manifested by tremor, paralysis, and wasting. The neurovirulence of these viruses has long been known to be determined by the sequence of the viral envelope protein, although the nature of the neurotoxicity r...

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Bibliographic Details
Main Authors: Portis, J. L., Askovich, P., Austin, J., Gutierrez-Cotto, Y., McAtee, F. J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687393/
https://ncbi.nlm.nih.gov/pubmed/19339354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02647-08
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