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A Dominant-Negative Mutant of rab5 Inhibits Infection of Cells by Foot-and-Mouth Disease Virus: Implications for Virus Entry

Foot-and-mouth disease virus (FMDV) can use a number of different integrins (αvβ1, αvβ3, αvβ6, and αvβ8) as receptors to initiate infection. Infection mediated by αvβ6 is known to occur by clathrin-mediated endocytosis and is dependent on the acidic pH within endosomes. On internalization, virus is...

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Detalhes bibliográficos
Main Authors: Johns, Helen L., Berryman, Stephen, Monaghan, Paul, Belsham, Graham J., Jackson, Terry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687373/
https://ncbi.nlm.nih.gov/pubmed/19357169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02460-08
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