Atorvastatin Is a Promising Partner for Antimalarial Drugs in Treatment of Plasmodium falciparum Malaria

Atorvastatin (AVA) is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. AVA exposure resulted in the reduced in vitro growth of 22 Plasmodium falciparum strains, with the 50% inhibitory concentrations (IC(50)s) ranging from 2.5 μM to 10.8 μM. A significant positive correlation was found b...

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Bibliografiske detaljer
Main Authors: Parquet, Véronique, Briolant, Sébastien, Torrentino-Madamet, Marylin, Henry, Maud, Almeras, Lionel, Amalvict, Rémy, Baret, Eric, Fusaï, Thierry, Rogier, Christophe, Pradines, Bruno
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Susceptibility
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687225/
https://ncbi.nlm.nih.gov/pubmed/19307369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01462-08
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