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Prion Protein Expression and Processing in Human Mononuclear Cells: The Impact of the Codon 129 Prion Gene Polymorphism

BACKGROUND: So far, all clinical cases of new variant Creutzfeldt-Jakob disease (vCJD), thought to result from the Bovine Spongiform Encephalopathy (BSE) prion agent, have shown Methionine–Methionine (M/M) homozygosity at the M129V polymorphism of the PRNP gene. Although established, this relationsh...

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Bibliografske podrobnosti
Main Authors: Segarra, Christiane, Lehmann, Sylvain, Coste, Joliette
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686158/
https://ncbi.nlm.nih.gov/pubmed/19495414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005796
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