Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia

Neutropenia and related infections are the most important dose-limiting toxicities in anticancer chemotherapy and radiotherapy. In this study, we explored a new strategy for augmenting host defense in neutropenia-related pneumonia. Phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) signali...

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Autors principals: Li, Yitang, Jia, Yonghui, Pichavant, Muriel, Loison, Fabien, Sarraj, Bara, Kasorn, Anongnard, You, Jian, Robson, Bryanne E., Umetsu, Dale T., Mizgerd, Joseph P., Ye, Keqiang, Luo, Hongbo R.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2009
Matèries:
Phagocytes, Granulocytes, and Myelopoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686143/
https://ncbi.nlm.nih.gov/pubmed/19286998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-161414
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