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A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney

The mammalian kidney is organized into a cortex where primary filtration occurs, and a medullary region composed of elongated tubular epithelia where urine is concentrated. We show that the cortico-medullary axis of kidney organization and function is regulated by Wnt7b signaling. The future collect...

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Библиографические подробности
Главные авторы: Yu, Jing, Carroll, Thomas J., Rajagopal, Jay, Kobayashi, Akio, Ren, Qun, McMahon, Andrew P.
Формат: Artigo
Язык:Inglês
Опубликовано: Company of Biologists 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685965/
https://ncbi.nlm.nih.gov/pubmed/19060336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.022087
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