Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females

Mutations in the X-linked aristaless-related homeobox gene (ARX) have been linked to structural brain anomalies as well as multiple neurocognitive deficits. The generation of Arx-deficient mice revealed several morphological anomalies, resembling those observed in patients and an interneuron migrati...

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Detalhes bibliográficos
Main Authors: Marsh, Eric, Fulp, Carl, Gomez, Ernest, Nasrallah, Ilya, Minarcik, Jeremy, Sudi, Jyotsna, Christian, Susan L., Mancini, Grazia, Labosky, Patricia, Dobyns, William, Brooks-Kayal, Amy, Golden, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685924/
https://ncbi.nlm.nih.gov/pubmed/19439424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awp107
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