Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT(2C)R-mediated behaviour

The Prader–Willi syndrome (PWS) genetic interval contains several brain-expressed small nucleolar (sno)RNA species that are subject to genomic imprinting. In vitro studies have shown that one of these snoRNA molecules, h/mbii-52, negatively regulates editing and alternative splicing of the serotonin...

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Main Authors: Doe, Christine M., Relkovic, Dinko, Garfield, Alastair S., Dalley, Jeffrey W., Theobald, David E.H., Humby, Trevor, Wilkinson, Lawrence S., Isles, Anthony R.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2009
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685753/
https://ncbi.nlm.nih.gov/pubmed/19304781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp137
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