Structural basis for the nuclease activity of a bacteriophage large terminase

The DNA-packaging motor in tailed bacteriophages requires nuclease activity to ensure that the genome is packaged correctly. This nuclease activity is tightly regulated as the enzyme is inactive for the duration of DNA translocation. Here, we report the X-ray structure of the large terminase nucleas...

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Main Authors: Smits, Callum, Chechik, Maria, Kovalevskiy, Oleg V, Shevtsov, Mikhail B, Foster, Andrew W, Alonso, Juan C, Antson, Alfred A
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2009
主題:
Scientific Report
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685612/
https://ncbi.nlm.nih.gov/pubmed/19444313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.53
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