ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice

Sildenafil, a selective inhibitor of phosphodiesterase type 5, induces powerful protection against myocardial ischemia-reperfusion injury through activation of cGMP-dependent protein kinase (PKG). We further hypothesized that PKG-dependent activation of survival kinase ERK may play a causative role...

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Hlavní autoři: Das, Anindita, Salloum, Fadi N., Xi, Lei, Rao, Yuan J., Kukreja, Rakesh C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2009
Témata:
Translational Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685342/
https://ncbi.nlm.nih.gov/pubmed/19286961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00100.2009
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