CK1δ modulates the transcriptional activity of ERα via AIB1 in an estrogen-dependent manner and regulates ERα–AIB1 interactions

Oncogenesis in breast cancer often requires the overexpression of the nuclear receptor coactivator AIB1/SRC-3 acting in conjunction with estrogen receptor-α (ERα). Phosphorylation of both ERα and AIB1 has been shown to have profound effects on their functions. In addition, proteasome-mediated degrad...

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Bibliographic Details
Main Authors: Giamas, Georgios, Castellano, Leandro, Feng, Qin, Knippschild, Uwe, Jacob, Jimmy, Thomas, Ross S., Coombes, R. Charles, Smith, Carolyn L., Jiao, Long R., Stebbing, Justin
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685087/
https://ncbi.nlm.nih.gov/pubmed/19339517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp136
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