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Phospholipase C-Mediated Regulation of Transient Receptor Potential Vanilloid 6 Channels: Implications in Active Intestinal Ca(2+) Transport

Transient receptor potential vanilloid 6 (TRPV6) channels play an important role in intestinal Ca(2+) transport. These channels undergo Ca(2+)-induced inactivation. Here we show that Ca(2+) flowing through these channels activates phospholipase C (PLC) leading to the depletion of phosphatidylinosito...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Thyagarajan, Baskaran, Benn, Bryan S., Christakos, Sylvia, Rohacs, Tibor
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Pharmacology and Experimental Therapeutics 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684912/
https://ncbi.nlm.nih.gov/pubmed/19073818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.052449
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