Angiotensin-(1–7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells

Background. In the diabetic kidney, stimulation of mitogen-activated protein kinases (MAPKs) leads to extracellular matrix protein synthesis. In the proximal tubule, angiotensin-(1–7) [Ang-(1–7)] blocks activation of MAPKs by angiotensin II. We studied the effect of Ang-(1–7) on signalling responses...

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Detalhes bibliográficos
Main Authors: Gava, Elisandra, Samad-Zadeh, Arman, Zimpelmann, Joseph, Bahramifarid, Nasim, Kitten, Gregory T., Santos, Robson A., Touyz, Rhian M., Burns, Kevin D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Experimental Nephrology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684752/
https://ncbi.nlm.nih.gov/pubmed/19144997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfn736
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