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Sonic hedgehog: its expression in a healing cornea and its role in neovascularization

PURPOSE: To examine if sonic hedgehog (Shh) is involved in tissue neovascularization by using cell culture and an animal cornea. METHODS: The effects of exogenous Shh (5.0 nM), vascular endothelial growth factor (VEGF), and/or a Shh signal inhibitor (2.5 or 10.0 μM cyclopamine) on vessel-like tube f...

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Detalhes bibliográficos
Main Authors: Fujita, Kyoko, Miyamoto, Takeshi, Saika, Shizuya
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Vision 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684749/
https://ncbi.nlm.nih.gov/pubmed/19471603
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