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Progestins Activate the AKT Pathway in Leiomyoma Cells and Promote Survival

Context: Progesterone has been associated with promoting growth of uterine leiomyomas. The mechanisms involved remain unclear. Objective: In this study we investigated the activation of the AKT pathway and its downstream effectors, glycogen synthase kinase-3b and Forkhead box O (FOXO)-1 by progester...

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Detalhes bibliográficos
Main Authors: Hoekstra, Anna V., Sefton, Elizabeth C., Berry, Emily, Lu, Zhenxiao, Hardt, Jennifer, Marsh, Erica, Yin, Ping, Clardy, Jon, Chakravarti, Debabrata, Bulun, Serdar, Kim, J. Julie
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684476/
https://ncbi.nlm.nih.gov/pubmed/19240153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2008-2093
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