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Scratching Behavior and Fos Expression in Superficial Dorsal Horn Elicited by Protease-Activated Receptor Agonists and Other Itch Mediators in Mice

Protease-activated receptor (PAR)-2 and PAR-4 are implicated in nonhistaminergic itch. We investigated dose dependence, tachyphylaxis, and cross-tachyphylaxis of itch-associated scratching elicited by intradermal injections of PAR-2 and PAR-4 agonists, serotonin (5-hydroxytryptamine, 5-HT), and hist...

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Detalhes bibliográficos
Main Authors: Akiyama, Tasuku, Merrill, Austin W., Zanotto, Karen, Carstens, Mirela Iodi, Carstens, E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683773/
https://ncbi.nlm.nih.gov/pubmed/19293390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.152256
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