Fenofibrate Metabolism in the Cynomolgus Monkey using Ultraperformance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics

Fenofibrate, widely used for the treatment of dyslipidemia, activates the nuclear receptor, peroxisome proliferator-activated receptor α. However, liver toxicity, including liver cancer, occurs in rodents treated with fibrate drugs. Marked species differences occur in response to fibrate drugs, espe...

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Detalhes bibliográficos
Main Authors: Liu, Aiming, Patterson, Andrew D., Yang, Zongtao, Zhang, Xinying, Liu, Wei, Qiu, Fayang, Sun, He, Krausz, Kristopher W., Idle, Jeffrey R., Gonzalez, Frank J., Dai, Renke
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683687/
https://ncbi.nlm.nih.gov/pubmed/19251819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.025817
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