Constitutive Androstane Receptor-Mediated Changes in Bile Acid Composition Contributes to Hepatoprotection from Lithocholic Acid-Induced Liver Injury in Mice

Pharmacological activation of the constitutive androstane receptor (CAR) protects the liver during cholestasis. The current study evaluates how activation of CAR influences genes involved in bile acid biosynthesis as a mechanism of hepatoprotection during bile acid-induced liver injury. CAR activato...

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Main Authors: Beilke, Lisa D., Aleksunes, Lauren M., Holland, Ricky D., Besselsen, David G., Beger, Rick D., Klaassen, Curtis D., Cherrington, Nathan J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683394/
https://ncbi.nlm.nih.gov/pubmed/19196849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.023317
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