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Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected children

HIV-1 infection induces a progressive disruption of the B cell compartment impairing long-term immune responses to routine immunizations. Depletion of specific memory B cell pools occurs during the 1st stages of the infection and cannot be reestablished by antiretroviral treatment. We reasoned that...

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Main Authors: Pensieroso, Simone, Cagigi, Alberto, Palma, Paolo, Nilsson, Anna, Capponi, Claudia, Freda, Elio, Bernardi, Stefania, Thorstensson, Rigmor, Chiodi, Francesca, Rossi, Paolo
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683072/
https://ncbi.nlm.nih.gov/pubmed/19416836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901702106
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