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Inhibitory Mechanism of Escherichia coli RelE-RelB Toxin-Antitoxin Module Involves a Helix Displacement Near an mRNA Interferase Active Site

In Escherichia coli, RelE toxin participates in growth arrest and cell death by inducing mRNA degradation at the ribosomal A-site under stress conditions. The NMR structures of a mutant of E. coli RelE toxin, RelE(R81A/R83A), with reduced toxicity and its complex with an inhibitory peptide from RelB...

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מידע ביבליוגרפי
Main Authors: Li, Guang-Yao, Zhang, Yonglong, Inouye, Masayori, Ikura, Mitsuhiko
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682910/
https://ncbi.nlm.nih.gov/pubmed/19297318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809656200
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