Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic β-Cells Leads to Increased β-Cell Mass and Prevention of Hyperglycemia

OBJECTIVE: Components of insulin/IGF-1 receptor–mediated signaling pathways in pancreatic β-cells have been implicated in the development of diabetes, in part through the regulation of β-cell mass in vivo. Studies in vitro have shown that the protein Ras homolog enriched in brain (Rheb) plays a key...

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Main Authors: Hamada, Suirin, Hara, Kenta, Hamada, Takeshi, Yasuda, Hisafumi, Moriyama, Hiroaki, Nakayama, Rika, Nagata, Masao, Yokono, Koichi
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2009
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682691/
https://ncbi.nlm.nih.gov/pubmed/19258434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0519
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