G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release: Studies Involving 19,605 Europeans

OBJECTIVE: Genome-wide association studies have identified several variants within the MTNR1B locus that are associated with fasting plasma glucose (FPG) and type 2 diabetes. We refined the association signal by direct genotyping and examined for associations of the variant displaying the most indep...

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Auteurs principaux: Sparsø, Thomas, Bonnefond, Amélie, Andersson, Ehm, Bouatia-Naji, Nabila, Holmkvist, Johan, Wegner, Lise, Grarup, Niels, Gjesing, Anette P., Banasik, Karina, Cavalcanti-Proença, Christine, Marchand, Marion, Vaxillaire, Martine, Charpentier, Guillaume, Jarvelin, Marjo-Riitta, Tichet, Jean, Balkau, Beverley, Marre, Michel, Lévy-Marchal, Claire, Færch, Kristine, Borch-Johnsen, Knut, Jørgensen, Torben, Madsbad, Sten, Poulsen, Pernille, Vaag, Allan, Dina, Christian, Hansen, Torben, Pedersen, Oluf, Froguel, Philippe
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2009
Sujets:
Genetics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682679/
https://ncbi.nlm.nih.gov/pubmed/19324940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1660
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