A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C) by interacting with the LDL receptor (LDLR) and is an attractive therapeutic target for LDL-C lowering. We have generated a neutralizing anti-PCSK9 antibody, mAb1, that binds to an epitope on PCSK9 adjacent...

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Detalhes bibliográficos
Main Authors: Chan, Joyce C. Y., Piper, Derek E., Cao, Qiong, Liu, Dongming, King, Chadwick, Wang, Wei, Tang, Jie, Liu, Qiang, Higbee, Jared, Xia, Zhen, Di, Yongmei, Shetterly, Susan, Arimura, Ziva, Salomonis, Heather, Romanow, William G., Thibault, Stephen T., Zhang, Richard, Cao, Ping, Yang, Xiao-Ping, Yu, Timothy, Lu, Mei, Retter, Marc W., Kwon, Gayle, Henne, Kirk, Pan, Oscar, Tsai, Mei-Mei, Fuchslocher, Bryna, Yang, Evelyn, Zhou, Lei, Lee, Ki Jeong, Daris, Mark, Sheng, Jackie, Wang, Yan, Shen, Wenyan D., Yeh, Wen-Chen, Emery, Maurice, Walker, Nigel P. C., Shan, Bei, Schwarz, Margrit, Jackson, Simon M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682542/
https://ncbi.nlm.nih.gov/pubmed/19443683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903849106
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