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Repositioning HIV Protease Inhibitors as Cancer Therapeutics
PURPOSE OF REVIEW: Though designed to target only the HIV protease, HIV protease inhibitors (PIs) induce toxicities in patients such as insulin resistance and lipodystrophy that suggest that PIs have other targets in mammalian cells. Akt controls insulin signaling and is an important target in cance...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2682221/ https://ncbi.nlm.nih.gov/pubmed/19373040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/COH.0b013e328313915d |
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