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Structural Adaptation and Heterogeneity of Normal and Tumor Microvascular Networks

Relative to normal tissues, tumor microcirculation exhibits high structural and functional heterogeneity leading to hypoxic regions and impairing treatment efficacy. Here, computational simulations of blood vessel structural adaptation are used to explore the hypothesis that abnormal adaptive respon...

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Detalhes bibliográficos
Main Authors: Pries, Axel R., Cornelissen, Annemiek J. M., Sloot, Anoek A., Hinkeldey, Marlene, Dreher, Matthew R., Höpfner, Michael, Dewhirst, Mark W., Secomb, Timothy W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682204/
https://ncbi.nlm.nih.gov/pubmed/19478883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000394
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