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Protein Kinase PKR-Dependent Activation of Mitogen-Activated Protein Kinases Occurs through Mitochondrial Adapter IPS-1 and Is Antagonized by Vaccinia Virus E3L

The p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs) play important roles in the host innate immune response. The protein kinase regulated by RNA (PKR) is implicated in p38 MAPK activation in response to proinflammatory signals in mouse embryonic fibroblasts. To test t...

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Bibliografiske detaljer
Main Authors: Zhang, Ping, Langland, Jeffrey O., Jacobs, Bertram L., Samuel, Charles E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681938/
https://ncbi.nlm.nih.gov/pubmed/19321614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00224-09
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