Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain

Most human immunodeficiency virus type 1 (HIV-1) strains isolated from the brain use CCR5 for entry into macrophages and microglia. Strains that use both CCR5 and CXCR4 for entry (R5X4 strains) have been identified in the brains of some individuals, but mechanisms underlying the persistence of R5X4...

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Hauptverfasser: Gray, Lachlan, Roche, Michael, Churchill, Melissa J., Sterjovski, Jasminka, Ellett, Anne, Poumbourios, Pantelis, Sheffief, Shameem, Wang, Bin, Saksena, Nitin, Purcell, Damian F. J., Wesselingh, Steven, Cunningham, Anthony L., Brew, Bruce J., Gabuzda, Dana, Gorry, Paul R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681927/
https://ncbi.nlm.nih.gov/pubmed/19321618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02648-08
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