Cleavage of Escherichia coli Cytotoxic Necrotizing Factor 1 Is Required for Full Biologic Activity

Cytotoxic necrotizing factor 1 (CNF1) is a protein toxin produced by pathogenic Escherichia coli strains. CNF1 constitutively activates small GTPases of the Rho family by deamidation of a glutamine, which is crucial for GTP hydrolysis. The toxin is taken up into mammalian cells by receptor-mediated...

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Bibliographic Details
Main Authors: Knust, Zeynep, Blumenthal, Britta, Aktories, Klaus, Schmidt, Gudula
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681735/
https://ncbi.nlm.nih.gov/pubmed/19237521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01145-08
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