A DNA Vaccine Encoding the Enterohemorragic Escherichia coli Shiga-Like Toxin 2 A(2) and B Subunits Confers Protective Immunity to Shiga Toxin Challenge in the Murine Model

Production of verocytotoxin or Shiga-like toxin (Stx), particularly Stx2, is the basis of hemolytic uremic syndrome, a frequently lethal outcome for subjects infected with Stx2-producing enterohemorrhagic Escherichia coli (EHEC) strains. The toxin is formed by a single A subunit, which promotes prot...

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Detalhes bibliográficos
Main Authors: Bentancor, Leticia V., Bilen, Marcos, Brando, Romina J. Fernández, Ramos, María Victoria, Ferreira, Luis C. S., Ghiringhelli, Pablo D., Palermo, Marina S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Vaccine Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681575/
https://ncbi.nlm.nih.gov/pubmed/19176691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00328-08
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