Chemical Modifications of Antisense Morpholino Oligomers Enhance Their Efficacy against Ebola Virus Infection

Phosphorodiamidate morpholino oligomers (PMOs) are uncharged nucleic acid-like molecules designed to inactivate the expression of specific genes via the antisense-based steric hindrance of mRNA translation. PMOs have been successful at knocking out viral gene expression and replication in the case o...

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Bibliographische Detailangaben
Hauptverfasser: Swenson, Dana L., Warfield, Kelly L., Warren, Travis K., Lovejoy, Candace, Hassinger, Jed N., Ruthel, Gordon, Blouch, Robert E., Moulton, Hong M., Weller, Dwight D., Iversen, Patrick L., Bavari, Sina
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681561/
https://ncbi.nlm.nih.gov/pubmed/19223614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00936-08
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