Suppressed Ca(2+)/CaM/CaMKII-dependent K(ATP) channel activity in primary afferent neurons mediates hyperalgesia after axotomy

Painful axotomy decreases K(ATP) channel current (IK(ATP)) in primary afferent neurons. Because cytosolic Ca(2+) signaling is depressed in injured dorsal root ganglia (DRG) neurons, we investigated whether Ca(2+)–calmodulin (CaM)–Ca(2+)/CaM-dependent kinase II (CaMKII) regulates IK(ATP) in large DRG...

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Detalhes bibliográficos
Main Authors: Kawano, Takashi, Zoga, Vasiliki, Gemes, Geza, McCallum, J. Bruce, Wu, Hsiang-En, Pravdic, Danijel, Liang, Mei-Ying, Kwok, Wai-Meng, Hogan, Quinn, Sarantopoulos, Constantine
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681318/
https://ncbi.nlm.nih.gov/pubmed/19439665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901815106
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