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Estradiol and Lithium Chloride Specifically Alter NMDA Receptor Subunit NR1 mRNA and Excitotoxicity in Primary Cultures
Glutamate facilitates calcium influx via NMDAR, and excess calcium influx increases excitotoxicity – a pathological characteristic of neurological diseases. Both 17β-estradiol (E2) and lithium influence NMDAR expression/signaling and excitotoxicity. This led us to hypothesize that combined E2 and li...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2681239/ https://ncbi.nlm.nih.gov/pubmed/19285052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2009.02.066 |
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