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Structure-based discovery of dengue virus protease inhibitors

Dengue virus belongs to the family Flaviviridae and is a major emerging pathogen for which the development of vaccines and antiviral therapy has seen little success. The NS3 viral protease is a potential target for antiviral drugs since it is required for virus replication. The goal of this study wa...

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Bibliographic Details
Main Authors: Tomlinson, Suzanne M., Malmstrom, Robert D., Russo, Andrew, Mueller, Niklaus, Pang, Yuan-Ping, Watowich, Stanley J.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680748/
https://ncbi.nlm.nih.gov/pubmed/19428601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2009.02.190
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