Different Thermodynamic Binding Mechanisms and Peptide Fine Specificities Associated with a Panel of Structurally Similar High-Affinity T Cell Receptors,

To understand the mechanisms that govern T cell receptor (TCR)–peptide MHC (pMHC) binding and the role that different regions of the TCR play in affinity and antigen specificity, we have studied the TCR from T cell clone 2C. High-affinity mutants of the 2C TCR that bind QL9-L(d) as a strong agonist...

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Detalhes bibliográficos
Main Authors: Jones, Lindsay L., Colf, Leremy A., Bankovich, Alexander J., Stone, Jennifer D., Gao, Yi-Gui, Chan, Choi Mui, Huang, Raven H., Garcia, K. Christopher, Kranz, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680728/
https://ncbi.nlm.nih.gov/pubmed/18973345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801349g
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