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Tumor suppression by p53 in the absence of Atm
Oncogenes can induce p53 through a signaling pathway involving p19/Arf. It was recently proposed that oncogenes can also induce DNA damage and this can induce p53 through the Atm DNA damage pathway. To assess the relative roles of Atm, Arf, and p53 in suppression of Ras- driven tumors we examined su...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2680228/ https://ncbi.nlm.nih.gov/pubmed/18583527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-07-2009 |
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